Supersymmetry (SUSY) is one of the most popular extensions of the Standard Model of Particle Physics as it provides both an elegant mechanism to stabilize the mass of the Higgs boson to the observed value and a suitable candidate for the Dark Matter of the Universe. After reviewing the motivations for Natural SUSY, some examples of the searches performed by the CMS experiment during LHC Run1 will be presented, particularly focusing on hadronic final states with high multiplicity of b-jets and large missing transverse energy. An overview of the new Run2 searches and estimated sensitivities for the near future at the LHC will be given.