It is attractive and interesting to introduce an extra Higgs doublet to the Standard Model, from the phenomenological point of view. The extended model could be interpreted as an effective model of many Beyond Standard Models, and the extension also provides a lot of interesting phenomenologies. In this talk, I briefly review the setup and summarize the current status of the two-Higgs-doublet models (2HDMs). I also explain the impact of the 2HDMs on the excesses in the flavor physics.