In this talk, I shall present new results on fermion masses and proton decay in the context of renormalizable SUSY SO(10) models. Difficulties with the minimal model are avoided by enlarging the symmetry breaking sector with a 54. Consistent fermion mass spectrum is obtained, including the neutrino sector. A mini-split SUSY spectrum is suggested by proton decay constraints, which is compatible with pure gravity mediation. A successful implementation of the Peccei-Quinn symmetry will be presented, in which case the model becomes compatible with proton lifetime with TeV scalars.